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  Ketoconazole and Zinc Pyrithione lotion

Ketoconazole & Zinc Pyrithione

LOTION PRESENTATION:
Each lotion contains:
Ketoconazole IP 2% w/v
Zinc Pyrithione IP 1% w/v
gel base q.s

ketoconazole and zinc Pyrithione are used together to treat skin conditions such as dandruff, psoriasis and seborrheic dermatitis. It Prevents the dry and scaly skin of the scalp, face, ears, chest due to fungal infection.

• Blastomycosis
• Candidiasis
• Chromomycosis
• Histoplasmosis
• Also used in Cushing syndrome
• Dandruff
• Seborrheic dermatitis

Ketoconazole-
Ketoconazole belongs to the imidazole antifungal drug which is used against the fungal infection. It falls into the broad-spectrum drug. Ketoconazole is used as 2% solution for the treatment of seborrheic dermatitis. There is greater reduction in the scaling, erythema, pruritis.

Zinc Pyrithione-
It is chelated complex of zinc and Pyrithione. It has antifungal and antibacterial, antimicrobial, bacteriostatic property that’s by it is used to treat dandruff and seborrheic dermatitis, acne or psoriasis. It inhibits the growth of yeast which is the main factor for causing dandruff. It is the main used ingredient of shampoo’s as antidandruff agent.

Ketoconazole acts on the enzyme 14-alpha- demethylase and inhibit its action. This enzyme is responsible for the synthesis of ergosterol which is the main component of the fungal membrane.

Zinc Pyrithione inhibits the action of copper induced growth induced in the bacterial membrane. Zinc is also reducing itching and redness which is associated with seborrheic dermatitis.

• Ketoconazole is mostly absorbed topically
• Ketoconazole is mainly bound to albumin in the plasma
• Ketoconazole undergoes oxidation in the liver
• It is excreted via urine
• Zinc Pyrithione is absorb from the skin
• It is metabolized by glucuronidation conjugation
• It is excreted via urine

• Burning sensation of the scalp
• Redness
• Dryness
• Open sores
• Swelling of eyes
• Allergic reactions

• Contraindicated in people with known hypersensitivity reaction.




Store it at room temperature.


• Ask your doctor before using this medication if you are allergic to it.
• Used only if needed in pregnancy.